CRED Understanding Clinical Development 2024

11/10/2024

PK variability

Blood flow Enzyme activity Transporter activity Renal & biliary function Gastrointestinal function

Pharmacokinetics

The Organisation for Professionals in Regulatory Affairs

19

Steady state and therapeutic window

Therapeutic Failure / Toxicity

Therapeutic Success

Therapeutic Failure

Plasma Drug Concentration

( Dose Time)

Time

The Organisation for Professionals in Regulatory Affairs

20

10