CRED Understanding Clinical Development 2024

11/10/2024

Mechanism of Action, Onset, and Duration

Molecular – Receptor, ion channel, enzyme, carrier molecules

Cellular – Transduction, e.g., G protein, ion channel, enzyme

Tissue – Contraction, secretion, metabolic activity, proliferation

System – Gastrointestinal, CNS, etc

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Mechanism of Action, Onset and Duration

Onset of action

Toxic range

Termination of action

Therapeutic range

Duration of action

Sub-therapeutic range

Plasma concentrations

Time

The Organisation for Professionals in Regulatory Affairs

10

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