Module 14 2022

22/03/2022

STEAM STERILISATION

• Z or z-value is used to determine the time values with different D- values at different temperatures with the following equation, where T = temperature in °C:

Death curves can be empirically established for all bactericidal agents. The D-value at an unknown temperature can be calculated knowing the D-value at a given temperature provided the Z-value is known.

Masterclass: Lecture 11

The Organisation for Professionals in Regulatory Affairs

17

AUTOCLAVING

– Suitable for objects and materials that can tolerate humidity, high pressure, high temperatures, such as – Surgical instruments – Semiconductors – up to 125°C – NOT suitable for many other types of component, e.g. batteries: – exposing embedded batteries to high temperatures significantly reduces their lifetime – memory devices that use floating-gate technology, such as EEPROMS

Masterclass: Lecture 11

The Organisation for Professionals in Regulatory Affairs

18

9