Module 14 2022

22/03/2022

CHLORINE DIOXIDE

● AS WITH ETO…Does not involve high temperatures / high humidity

– Also slower than STEAM – due to aeration stage: can range from hours to days

Masterclass: Lecture 11

The Organisation for Professionals in Regulatory Affairs

23

CHLORINE DIOXIDE STERILISATION

● Same basic stages as ETO – Acts as an oxidizing agent - reacts with several cellular constituents, including the cell membrane of microbes.

– By "stealing" electrons from them (oxidation), CD breaks their molecular bonds, resulting in the death of the organism by the break up of the cell.

– The potency of CD is attributable to the simultaneous, oxidative attack on many proteins, thereby preventing the cells from mutating to a resistant form.

– Because of the lower reactivity of CD, its antimicrobial action is retained longer in the presence of organic matter.

Masterclass: Lecture 11

The Organisation for Professionals in Regulatory Affairs

24

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