Module 18 2021

Schematic* of CTX0E03 Mechanism of Action

Formation of new blood vessels in or near to damaged brain region (angiogenesis)

Modulating the immune system from an inflammatory to a repair-promoting phenotype, leading to

CTX0E03 cells

Releasing growth factors and cytokines

Cells implanted in putamen (involved in motor function) near the area of stroke damage

Promotion of new neurons in the damaged region (neurogenesis)

* Images (except CTX0E03 cells top left) are for illustration only.

TOPRA MSc Module 18: Drug Device Combinations and other Technology