Module 18 2021

Example 4 - human endothelial cells cultured in a gelatin matrix

• To reduce the intimal thickening of vessels injured by the frequent procedures of artero-venous grafts and fistula placements in patients that undergo haemodialysis • Allogeneic endothelial cells release biological factors that inhibit the intimal hyperplasia, reduce the graft thrombosis, and repair the vascular injury • Matrix is CE marked medical device used for haemostasis • Gel matrix in the product keeps the cells close to the vascular injury site allowing the exposure to the biological factors

TOPRA MSc Module 18: Drug Device Combinations and other Technology