Module 18 - Drug Device Combinations and Other Technologies

04/12/2023

Example 1 – Neural stem cell for treatment of disability following ischaemic stroke

• Allogeneic human Neural Stem Cell (NSC) therapy • Conditionally immortalized (genetic modification) toallow larger scale manufacturing (not therapeutic) • Intracerebral administration by stereotactic brain surgery

TOPRA MSc Module 18: Drug Device Combinations and other Technology

25

Schematic Mechanism of Action

Formation of new blood vessels in or near to damaged brain region (angiogenesis)

Modulating the immune system from an inflammatory to a repair-promoting phenotype, leading to

Neural stem cells

Releasing growth factors and cytokines

Cells implanted in putamen (involved in motor function) near the area of stroke damage

Promotion of new neurons in the damaged region (neurogenesis)

* Images are for illustration only.

TOPRA MSc Module 18: Drug Device Combinations and other Technology

26

13