Module 18 - Drug Device Combinations and Other Technologies

04/12/2023

Example 3 - Dermagraft

Polyglactinmesh – CE marked medical device used alone for wound healing

Treatment of diabetic foot ulcers

Scaffold provides a substrate over which the patient’s own epithelial cells can migrate to close the wound

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Example 4 - human endothelial cells cultured in a gelatin matrix

• To reduce the intimal thickening of vessels injured by the frequent procedures of artero-venous grafts and fistula placements in patients that undergo haemodialysis • Allogeneic endothelial cells release biological factors that inhibit the intimal hyperplasia, reduce the graft thrombosis, and repair the vascular injury • Matrix is CE marked medical device used for haemostasis • Gel matrix in the product keeps the cells close to the vascular injury site allowing the exposure to the biological factors

TOPRA MSc Module 18: Drug Device Combinations and other Technology

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