Module 3 2019

Why Choice of Route is Important - 2

Linear Route ➢ Low yield of API (90% step yield over 7 steps is 48% overall) ➢ Maximum manipulation of increasingly complex (and costly) molecules

Convergent Route ➢ Higher yield of API (90% step yield over 6 steps is 65% overall) ➢ Reduces manipulation of complex molecules since Q and Y could still be relatively simple ➢ Q and Y could be

➢ Where is the RSM

(could be A with GMP cost implications)?

possible RSMs with reduced GMP costs

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