Module 3 Presentations

14/05/2024

Why Choice of Route is Important - 1

 Linear Route A  B  C  D  E  F  G  H  Convergent Route P  Q  R  G  H X  Y  Z   Best to investigate routes and decide on the desired industrial process early to maximise options for starting material choices (and need for GMP!)

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Why Choice of Route is Important - 2

Linear Route  Low yield of API (90% step yield over 7 steps is 48% overall)  Maximum manipulation of increasingly complex (and costly) molecules

Convergent Route  Higher yield of API (90% step yield over 6 steps is 65% overall)  Reduces manipulation of complex molecules since Q and Y could still be relatively simple  Q and Y could be

 Where is the RSM

(could be A with GMP cost implications)?

possible RSMs with reduced GMP costs

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