Module 3 Presentations

07/05/2024

Chemical modifications

Photolysis ● Chemical decomposition induced by light or other radiant energy.

Figure 60 Nifedipine photochemistry.

Source: Steven W. Baertschi / PharmaceuticalStress Testing

The Organisation for Professionals in Regulatory Affairs

23

Chemical modifications

Photolysis • Degradation by light • Many pharmaceutical compounds are light sensitive • Decomposition occurs through a range of mechanisms which are often complex • Photochemical decomposition may be prevented by: • Storing pharmaceutical agents in coloured glass containers, • By storing them in the dark

The Organisation for Professionals in Regulatory Affairs

24