Module 3 Presentations

07/05/2024

Example of Stems

Stem Pharmacologically

Related Group

Example INN cefuroxime (Zinacef) fluconazole (Diflucan)

cef

antibiotics derived from cephalosporanic acid systematic antifungals of the miconazole group

-conazole

-dronic acid -lukast

calcium metabolism regulators

alendronic acid (Fosamax)

antiasthmatics or antiallergics, not primarily antihistamines: leukotriene receptor antagonist

montelukast (Singulair)

-olol

ß-adrenoceptor antagonists

bisoprolol (Cardicor) ramipril (Tritace)

-pril, - prilat

angiotensin-converting enzyme inhibitors

-racetam -sartan -vastatin

amide type nootropic agents, piracetam derivatives

levetiracetam (Keppra) losartan (Cozaar) atorvastatin (Lipitor)

angiotensin II receptor antagonists antihyperlipidaemic substances, HMG CoA reductase inhibitors

-tidine

histamine-H2-receptor antagonists of the cimetidine group

ranitidine (Zantac)

The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances’ WHO 2011 (with examples)

Nomenclature and Characterisation of the Active Ingredient

The Organisation for Professionals in Regulatory Affairs

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Sources  INN: International Nonproprietary Names (INN) for pharmaceutical substances  INN in four languages  Procedure for selection  General principles  Subsequent lists of proposed and recommended INN: WHO Drug Information  BAN: British Approved Names : incorporating International Nonproprietary Names.  A dictionary of drug names for regulatory use in the UK  Names & guiding principles  Cross-index with proprietary names  Guidelines for construction of pharmaceutical trademarks  USAN: USP Dictionary of USAN and International Drug Names (US Pharmacopoeia)

Nomenclature and Characterisation of the Active Ingredient

The Organisation for Professionals in Regulatory Affairs

34