Module 3 - Strategic case studies in practice

ICH Q3D(R1) Guideline

Araya M, Olivares M, Pizarro F, González M, Speisky H, Uauy R. Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure. Am J Clin Nutr 2003;77(3):646-50. ATSDR. Profile for copper. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 2004. Hébert CD, Elwell MR, Travlos GS, Fitz CJ, Bucher JR. Subchronic toxicity of cupric sulfate administered in drinking water and feed to rats and mice. Fundam Appl Toxicol 1993;21:461-475. IPCS. Copper. Environmental Health Criteria 200. International Programme on Chemical Safety. World Health Organization, Geneva. 1998. Wapnir RA. Copper absorption and bioavailability. Am J Clin Nutr 1998;67(suppl):1054S- 60S.

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