Module 3 - Strategic case studies in practice

ICH Q3D(R1) Guideline

Chemical Safety. World Health Organization, Geneva. 1991.

Merget R; Kulzer R; Dierkes-Globisch A, Breitstadt R, Gebler A, Kniffka A, Artelt S, Koenig HP, Alt F, Vormberg R, Baur X, Schultze-Werninghaus G. Exposure-effect relationship of platinum salt allergy in a catalyst production plant: conclusions from a 5- year prospective cohort study. J Allergy Clin Immunol 2000;105:364-370. Merget R, Caspari C, Kulzer SA, Dierkes-Globisch R, Kniffka A, Degens P et al. Effectiveness of a medical surveillance program for the prevention of occupational asthma caused by platinum salts: a nested case control study. J Allergy Clin Immunol 2001;107:707-12. Pepys J, Pickering CAC, Hughes EG. Asthma due to inhaled chemical agents--complex salts of platinum. Clin Exp Allergy 1972;2:391-96. Pickering CAC. Inhalation tests with chemical allergens: complex salts of platinum. Proc R Soc Med 1972;65:2-4. Reichlmayr-Lais AM, Kirchgessner M, Bader R. Dose-response relationships of alimentary PtCl 2 and PtCl 4 in growing rats. J Trace Elem Electrolytes Health Dis 1992;6(3):183-7. US DoL (OHSA). 29 CRF 1910.1000 Table Z-1. Limits for air contaminants. U.S. Department of Labor. 2013. US EPA. Platinum-group metals. Environmental Health Effects Research Series 1977;EPA-600/1-77-040. US EPA. Toxicological review of halogenated platinum salts and platinum compounds. In support of summary information on the Integrated Risk Information System (IRIS). 2009. EPA/635/R-08/018

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