Module 3 - Strategic case studies in practice

After removing duplicates, 33 full articles published in English language have been scanned if they address the association of individual cancer risk with the exposure to N- nitrosamines. 17 articles addressing the association of carcinogenesis with N- nitrosamines have been identified.

List of epidemiological studies identified Authors Title

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Catsburg et.al. (2014)

Dietary sources of N- nitroso compounds and bladder cancer risk: Findings from the Los Angeles bladder cancer study Carcinogenic risk of N- Nitrosamines in Shanghai Drinking Water: Indications for the Use of Ozone Pre-treatment Dietary nitrosamines, heterocyclic amines, and risk of gastric cancer: A case-control study in Uruguay Meat consumption and risk of stomach cancer in Uruguay: A case-control study Lifetime exposure to rubber dusts, fumes and N- nitrosamines and cancer mortality in a cohort of British rubber workers with 49 years follow-up Endogenous versus exogenous exposure to N- nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC- EURGAST) study Dietary N- nitroso compounds, endogenous nitrosation, and the risk of oesophageal and gastric cancer subtypes in the Netherlands Cohort Study Meat consumption and the risk of Barrett’s oesophagus in a large Dutch cohort Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N- nitroso compounds: A follow-up study Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women

cited

Chen et al. (2019)

not mentioned: no individual cancer risk has been evaluated

De Stefani et al. (2001) De Stefani et al. (1996) Hidajat et al. (2019) Jakszyn et al. (2006) Keszei, Goldbohm, et al. (2013) Keszei, Schouten, et al. (2013) Knekt et al. (1999) Larsson, Bergkvist, and Wolk (2006) La Vecchia et al. (1995)

cited

not mentioned: study population overlapped with other study

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not mentioned: study population overlapped with other study

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Nitrosamine intake and gastric cancer risk

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EMA/369136/2020

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