Module 6

Cardiohype Prescribing Information: Presentations : Tablets containing metoapril 5mg, 10mg & 20mg. Indications : Mild to moderate hypertension. Dosage and Administration : Initially 5mg once daily titrated upwards to usual maintenance dose 10-20mg once daily to be taken after food. Maximum dose 40mg in divided doses. Discontinue any diuretic 2 to 3 days before treatment commences. Reduced maintenance dose may be required in impaired renal function. Monitor patients with impaired liver function. Not recommended for children. Contraindications : Hypersensitivity to metoapril, pregnancy and lactation. History of angioneurotic oedema. Precautions : Renal function should be assessed prior to commencing therapy and during therapy where appropriate. Caution in patients with ischaemic heart or cerebrovascular disease, renal insufficiency, renovascular hypertension.. Hypotension may occur especially in cerebrovascular disease or in volume-depleted patients, surgery/anaesthesia. Potassium supplements, potassium-sparing diuretics, and potassium-containing salt substitutes are not recommended. Cardiohype should not be used in aortic stenosis or outflow obstruction. Afro-Caribbean patients may show reduced therapeutic response. Side-effects : Mainly transient and mild. Headaches, dizziness, fatigue, dyspepsia, nausea, rash, cough and hypotension. Rarely angioneurotic oedema, other hypersensitivity reactions, abdominal pain, diarrhoea, jaundice, mood alteration. Pancreatitis has been reported in patients on ACE inhibitors. Legal Category: POM. Marketing Authorisation Numbers and Basic NHS Cost: Cardiohype Tablets 5mg (0747/1415) (green), packs of 28 £6.25, 10mg (0747/1416) (pink) £10.43, 20mg (0747/1417) (yellow) £15.51. Marketing Authorisation Holder Apex & Nadir Pharmaceuticals, Northside, Clapham CL4 U5E Prescribing information last revised : December 2015. References : 1 Kindheart R, ‘Management of Hypertension – the Cardiohype Experience’, Satellite Symposium, Congress of Cardiology, Nice 2013. 2 MIMS, December 2015, 3 Wellington G et al , J. of Roy. Soc. of Cardiology, 2012, 35, 1606 4 Data on File. Leaflet prepared January 2016.

Prescribe the best ACE inhibitor

Why Prescribe

Prescribe Cardiohype !

CARDIOHYPE ?

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Longer acting

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Convenient once daily dosage

Uncaptioned photograph of Professor Kindheart delivering paper at satellite symposium Nice.

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Low cost

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Significantly improved survival rates in CHD

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Proven safety and efficacy

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Unsurpassed efficacy

Business Reply Service Licence No 1234

“The demonstrated improvement in survival rates for CHD patients on metoapril with its established efficacy and safety profile makes metoapril a first choice in the treatment of hypertension” 1

CARDIOHYPE

Apex & Nadir Pharmaceuticals Northside Clapham CL4 U5E

The first choice in cost-effective treatment for mild to moderate hypertension.

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