Module 9 2021

23/03/2021

Specific Considerations for Vaccines Clinical

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No Harm Principle

Vaccines target usually healthy population, often infants or children  Target population may have specific characteristics  Vaccine effect can vary e.g. high malaria prevalence, nutrition, health status  Vaccine effect can vary because of variation in prevailing disease – different vaccine may be needed (e.g. Malaria caused by Plasmodium falciparum - Plasmodium vivax )  Vaccine schedule is adapted to population: concomitant medicines or vaccines, disease pressure

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