Module 9 2021

Classification: are all genetically modified cells GTPs?

Ex vivo modified cells to complement a non functional gene for monogenic disease Ex vivo modified T cells with suicide genes for GvHD Ex vivo electroporated DC with mRNA for antitumour response

No direct link with the primary PD action

Transient expression, no mRNA administration

Direct link with the primary PD action

GTMP

NO GTMP

The difference is determined by the function and presence of the transgene

Novartis Pharma AG- Business use only- not for further distribution

34