Module 9 2024

03/09/2024

The Growth of Vaccines that can Prevent Disease

>30 diseases are currently preventable by vaccination

Covid

Zoster

Men B

Adjuvant Descriptions: MF59 = Squalene (oil-in-water adjuvant) e.g. used in influenzae vaccines AS04 = Mixture of monophosphoryl lipid A (MPL) and aluminium hydroxide e.g. used in HPV vaccine RC529 = A synthetic form of MPL ISA 51 = Mineral oil adjuvant AS03 = Squalene-based immunologic adjuvant e.g. used in pandemic flu vaccine AS01 = Liposome-based vaccine adjuvant system containing two immunostimulants: MPL and the saponin QS-21 CpG = Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs

Men ACWYconj

Pneumo conj HPV Rotavirus

MenC

Pa combo DTP HA/HB

Hepatitis A

Hib

Varicella

Hepatitis B rec

Hepatitis B

Pneumo PS Meningitis ACWY PS

CpG

Licensed adjuvants

Rubella

Mumps

AS01

Measles OPV (Sabin)

AS03

IPV (Salk)

ISA 51

Yellow fever

Influenza

RC529

Vaccine developed

Pertussis

AS04

Cholera

Tetanus

MF59 virosome

Tuberculosis

Rabies

Diphtheria

Smallpox

Typhoid

Aluminium salts

2020

1700 1800 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000

2010

Licensed adjuvant

Pre-industrial era

Industrial era

The Organisation for Professionals in Regulatory Affairs

Modified from Garçon N et al. Expert Rev Vaccines 2007;6:723 – 739

13

Regulatory Considerations for Prophylactic Vaccines

The Organisation for Professionals in Regulatory Affairs

14

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