Module 9 2024

03/09/2024

No Harm Principle

Vaccines target usually healthy population, often infants or children

⚫ Target population may have specific characteristics

▪ Vaccine effect can vary e.g. high malaria prevalence, nutrition, health status

▪ Vaccine effect can vary because of variation in prevailing disease – different vaccine may be needed (e.g. Malaria caused by Plasmodium falciparum - Plasmodium vivax )

▪ Vaccine schedule is adapted to population: concomitant medicines or vaccines, disease pressure

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Vaccines vs. Pharmaceutical Products - Study Populations

Vaccines

Pharmaceutical Products

Generally given prophylactically to people who are well

Generally given as treatments to people who are ill

Large study populations available – but recruitment for studies may be difficult as people may not realize an immediate ‘benefit’ from participation

Recruitment for studies easier as patients may find a ‘benefit’ in the experimental treatment vs. the current available options, but pool of patients to recruit from is small

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