Module 9 2024

03/09/2024

Potency in CAR-T T cell differentiation is associated with CR/PR, in vivo persistence, proliferation and apoptosis

CAR-T is an heterogenous with different genomic signatures characterizing CR and upregulation of immunosuppressive factors FOXP3 and IL27 and IL10 cytokines in RL

Is it only a question of quantity?

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Potency – Impact of Process Manufacturing

Expansion less manufacturing process preserves T cell stemness

Differential gene expression of tisa-cell versus YTB323 final product

Gene profiling in responder and non responder patients allowed to identified a set of highly expressed genes correlating with M3 and M6 positive response and in-vitro killing activity

The Organisation for Professionals in Regulatory Affairs

38

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