Module 9 2024

03/09/2024

How Does a Monoclonal Work - rituximab

NK NKT

B Cell

B Cell Aptosis

Complement Activation

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Potency Strategy Linked to MoA

Example 2: Bevacizumab (Avastin)

Binds to target VEGF via the Fab region to prevent the tumor developing blood vessels to support its growth, but as it is binding soluble VEGF it does not crucially also recruit the immune system as part of its potency, it simply binds VEGF and removes it.

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