Spring Intro 2023

06/03/2023

The Central Dogma of Biology is key to biotechnology products

Cytoplasm

Nucleus

Protein

Glycosylation Folding Cross-linking

Cell DNA

Ribosome

mRNA

Secretion

t-RNA amino acid

m-RNA

Translation

Complete protein

Transcription

5

Biotech medicines are larger and more complicated than chemical medicines

Aspirin 180 daltons

Insulin 51 amino-acids ~6,000 daltons

Somatropin 191 amino-acids ~22,000 daltons

Development must account for their complex structure and function

IgG1 antibody >1000 amino-acids ~150,000 daltons

6