Module 5 Presentations

05/07/2024

Further development Placebo

1863 Dr. Austin Flint - the first placebo experiment

• 13 patients with rheumatism treated with herbal tonic rather than with medicine known to be effective.

• Flint’s experiment did not compare the two against each other in the same trial but this was a significant step forward; contrasting the consequences of an active treatment with the natural course of an untreated disease.

• For the first time the terms “placebo” or “ placeboic remedy ” was used in a clinical trial.

The Organisation for Professionals in Regulatory Affairs

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Development of GCP Statistics

1925 Ronald Aylmer Fischer (1890–1962)

• English statistician, evolutionary biologist, mathematician

• “Statistical Methods for Research Workers” , published in 1925, influenced the practical use of statistics in many fields of study and is one of the 20th century's most influential books • Many important contributions to statistics, including the analysis of variance ( ANOVA ).

The Organisation for Professionals in Regulatory Affairs

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