CRED Understanding Clinical Development 2024

11/10/2024

Bioavailability (F)

Bioavailability = AUC 0 (F)

AUC iv

iv

oral

Plasma Concentration

Time

Definition = This is the fraction of a dose that reaches the systemic circulation following extravascular administration

The Organisation for Professionals in Regulatory Affairs

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Bioavailability (F)

Relative F – comparison of F between formulations of a drug given by the same or different routes of administration

Absolute F is usually assessed with reference to an intravenous dose

Absolute F

Relative F

The Organisation for Professionals in Regulatory Affairs

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