CRED Understanding Clinical Development 2024

11/10/2024

Apparent Volume of Distribution

Hypothetical volume in which the drug is dissolved after absorption. Relates amount of drug in the body to the concentration of drug in blood.

Amount in the body conc

Dose Initial conc

V d =

=

● If drug is avidly bound in tissues, the concentration in plasma will be low and V d may greatly exceed total body water.

● If drug is highly bound in plasma Vd will approach plasma volume

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Clearance

Volume of plasma from which drug is removed per unit time

KIDNEY

LIVER

Clearance

Renal Clearance

Hepatic Clearance

Filtration

Metabolism

Transport

Active transport

CL TOT = CL H + CL R

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6