CRED Understanding Clinical Development 2024

11/10/2024

Clearance

Clearance Drug Eliminated

Conc

Time

100 ml V d

Zero

1 mg/ml

10 ml/min

10 mg

100 mg Drug

100 ml V d

1 min

0.9 mg/ml

10 ml/min

9 mg

Drug

90 mg

100 ml V d

0.81 mg/ml

10 ml/min

8.1 mg

2 min

Drug

Remains constant Reduces each minute

81 mg

The Organisation for Professionals in Regulatory Affairs

Rate of drug elimination Conc

=

13

Effect of CL on concentrations

The Organisation for Professionals in Regulatory Affairs

14

7