Module 3 Presentations

07/05/2024

Potential Isomerism: Asymmetric Carbons  Chiral: Molecules containing a carbon atom attached to four different groups or atoms  One chiral center:

– Two enantiomers (enantiomorphs) – Non-superimposable mirror images – Optically active – Individual isomers: other properties the same

 Racemate:

– Optically inactive – Some other properties differ (mp, solubility)

Nomenclature and Characterisation of the Active Ingredient

The Organisation for Professionals in Regulatory Affairs

23

Example: Thalidomide

 Administered as a racemate  (R) isomer - effective sedative  (S) isomer – teratogenic properties causing foetaldeformities  Also undergoes racemisation in vivo

Nomenclature and Characterisation of the Active Ingredient

The Organisation for Professionals in Regulatory Affairs

24