Module 9 2021

Examples and applications

Vector for genetic modification • Plasmid / RNA • Integrating and non integrating vectors (including RNAi ) Gene editing • Zink finger nucleases • TALENS • CRISPR/Cas9 Examples & Applications • Gene replacement for monogenic inheriteded disease • Primary immunodeficiencies, metabolic disorders • Poligenic diseases: anti-tumour therapy via direct, bystander or suicide mechanisms • Immune mediated killing of tumour cells (CAR-T and UCART)

Novartis Pharma AG- Business use only- not for further distribution

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