Module 9 2021

Genome editing – Basis and principles

Precision editing for gene repair by introduction of double strand brakes ● Targeted genomic cleavage requires two key elements: homing device and endonuclease ● Adds, removes, alters genetic code at particular genomic locations ● Enables the direct, irreversible conversion of a specific DNA base into another

Adapted from Reimer: DIA – Feb 2019

Novartis Pharma AG- Business use only- not for further distribution

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