Spring Intro 2023

Mike Kelly

Definitions: 1

Pharmacokinetics (PK) ● The mathematical description of the time course of the movement drugs into, around and out of the body – i.e. the A bsorption, D istribution, M etabolism and E xcretion of drugs ( ADME ) ● What the body does to the drug

Pharmacodynamics (PD) ● What the drug and/or its metabolite(s) do to the body – desired - therapeutic or beneficial response – undesired - adverse or toxicological response Clinical Pharmacology • Science of linking the PK and PD of a drug

• Building a body of knowledge about the processes by which a drug enters, moves around and leaves the body (PK) and interacts with its sites of action and sites of toxicity (PD) • Exploring and understanding the factors which influence the exposure and response of the drug in the clinical setting, to ensure the correct clinical dose

3

Definitions: 2

 Biopharmaceutics ● The relationships between the formulation of the drug, the route of administration and the physiological/biochemical environment within the body

Biological Environment

Dose and Formulation

Route of Administration

BIOAVAILABILITY

4

2