Spring Intro 2023

Mike Kelly

Relationship Map

Biopharmaceutics

FORMULATION

Understand PK and PD relationship and influencing factors, to ensure appropriate dose for therapeutic outcome in patient population

BODY

Pharmacokinetics

Pharmacodynamics

RESPONSE

Efficacy/Adverse events

PATIENT DISEASE STATE

Therapeutic Outcome

5

Basic Principles: Pharmacokinetics

 Mathematical description of the time course of movement of drug around the body ● Plasma/blood concentration-time curves

Drug A bsorption Drug D istribution Drug M etabolism Drug E xcretion

Elimination }

Drug concentration

Time after dose

6

3